Objective: To observe the effect of Guizhi Mahuang Geban Tang (GMGT

Integrated Decoction of Ramulus Cinnamomi Decoction and Herba Ephedrae Decoction)

Yinqiao San (YS

Powder of Flos Lonicerae and Fructus Forsythiae)

and Xinjia Xiangru Yin (XXY

Modified Herba Moslae Powder) on interleukin 2 (IL-2) and T lymphocyte subgroups in mice infected with influenza A virus of type 1 or type 3. Method: NIH mice with specific pathogen free were given GMGT

YS and XXY(0.4mL·d-1

ig) respectively one day before the mice were attacked by intranasal dripping of 0.05 mL influenza A virus solution. After establishing the model

blood sample was collected on the fourth day

and the amount of IL-2 and CD＋3

CD＋4

CD＋8 in the blood was examined. Result: After infection

the peripheral IL-2 level in infected mice was decreased as compared with the normal group (P<0.05). YS had no significant effect on mice infected with type 3 influenza A virus. Both virazole and three exterior-releasing therapies increased the peripheral IL-2 level in mice infected with influenza A virus

and three exterior-releasing therapies increased the peripheral IL-2 level in mice infected with type 1 influenza A virus (P<0.05

compared with the normal group). CD＋3 and CD＋ 4 percentage in the mice infected with type 1 influenza A virus decreased as compared with those in the normal group (P<0.05)

and the decrease of CD＋4percentage in the infected mice was obvious

resulting in the lower CD+4/CD+8 (P<0.05 compared with the normal group). Three exterior-releasing therapies increased the total amount of CD＋3 and CD＋4(P<0.05

compared with the model group)

and increased the CD+8 (P<0.05

compared with the normal group) and CD+4/CD+8(P<0.05

compared with the model group)

being close to the normal level. Conclusion : The anti-virus mechanism of the three exterior-releasing therapies

GMGT

YS and XXY

is probably related with elevation of the cellular immune function.