Objective: To establish the best extraction method of Niuhuang Shangqing pellets. Method: L9 (34) orthogonal experiment was adopted to optimize the alcohol extraction process of rhubarb and baicalin with the yeild of emodin

chrysophanol and baicalin as evaluation target; L9 (34) orthogonal experiment was adopted to optimize the water extraction process of the rest herbs with the yeild of geniposide as evaluation target. Result :Optimum alcohol-extracting factors were 5 times of 70% alcohol

circum-fluence extracting for 1.5 h

for 3 times; Optimum water-extracting factors were 10 times of water

refluxing and extracting for 1h

for 2 times. Conclusion : The extraction method was designed reasonable and it was instructive to industrial production.