Objective:To study the pharmacological effects of extract from Andrographis paniculata Nees.Methods:By using antipyretic

anti-inflammatory

expectorant

antiviral

and immunomodulatory experiments

the pharmacological effects of extract from Andrographis paniculata Nees were investigated.Results:The extract from Andrographis paniculata Nees significantly inhibited yeast-induced fever in rats

and it lasted to 6 h.The extract significantly inhibited acetic acid-induced increase in capillary permeanbilitly in abdominal cavity of mice

inhibited carrageenin-induced foot swelling and cotton ball granulomatous hyperplasia in rats

suppressed the cough induced by ammonia solution in mice and the cough induced by sodium citrate in guinea pig

decreased the times of cough and increased cough latent period respectively

reduced lung inflammation induced by influenza virus in mice

increased the hemolysin antibody secretion of splenic lymphocyte in mice against the antibody secretion decreasing induced by cyclophosphamide in mice

enhanced phagocyte function of macrophage.Conclusion:The extract from Andrographis paniculata Nees demonstrates the effects of antipyretic

anti-inflammatory

expectorant

antiviral

and immunomodulatory.