Objective:To outlines the interaction between herbs metabolism and CYP450.Methods:Refer to more than 100 piece of literatures about CYP450 and sum up the article from conception of CYP450

study methods of CYP450

metabolism interaction and herbs metabolism.Results:study methods of CYP450 include methods in vitro and in vivo

and alteration in enzymic activity of CYP450 is reason of metabolism interaction.Conclusions:CYP450 plays an important role in drug metabolism;herbs have complicated ingredients and are reported to revoke some drug interaction often.The reason why drug interaction are caused by herbs is because these herbs affect activity or protein expression of CYP450 in organism and result in alteration of metabolism involved CYP450 of drugs thus to cause adverse drug reaction.