Objective: To investigate the anti-tumor and antioxidative effect of iridoid glucosides from Boschniakia rossica (IGBR) in VX2-bearing rabbits. Method: The VX2 transplanted rabbit model was established and the rabbits were randomly divided into 4 groups: model

high and low dose IGBR

and 5-Fu. Animals were treated with IGBR and the survival times of rabbits were recorded. In additional groups of rabbits treated with IGBR for 21 days

then the tumor weights were estimated and the growth inhibition ratios were calculated

and the serum activities of glutathione S -transferase (GST)

superoxide dismutase (SOD)

catalase (CAT)

glutathione peroxidase (GSH-PX)

as well as the content of malondialdehyde (MDA) were detected by colorimetric method. Result: The administration with IGBR prolonged the survival time

inhibited the growth of transplanted tumor

increased the serum activities of SOD

CAT and GSH-PX

and reduced the serum MDA level in VX2-bearing rabbits. Conclusion: IGBR could prolong the survival time of VX2-bearing rabbits

exhibit an inhibitory effect on the growth of transplanted VX2 tumor

probably via the improved anti-oxidative capability.