参麦注射液对心衰犬肿瘤坏死因子、 白介素1、白介素6的影响

王恒和; 毛静远; 张振鹏; 魏广力; 王贤良; 毕颖斐; 郭永铁

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参麦注射液对心衰犬肿瘤坏死因子、白介素1、白介素6的影响

更新时间：2024-01-04

- 参麦注射液对心衰犬肿瘤坏死因子、白介素1、白介素6的影响
- Effects of Injection on TNF-,IL-1,IL-6 in the Model Dogs with Heart Failure
- 中国实验方剂学杂志 2010年16卷第7期页码：105-107
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(30371752)
- DOI：
  中图分类号：
- 纸质出版日期：2010
- 稿件说明：
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王恒和, 毛静远, 张振鹏, 等. 参麦注射液对心衰犬肿瘤坏死因子、白介素1、白介素6的影响[J]. 中国实验方剂学杂志, 2010,16(7):105-107.

WANG Heng-he, MAO Jing-yuan, ZHANG Zhen-peng, et al. Effects of Injection on TNF-,IL-1,IL-6 in the Model Dogs with Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(7): 105-107.
王恒和, 毛静远, 张振鹏, 等. 参麦注射液对心衰犬肿瘤坏死因子、白介素1、白介素6的影响[J]. 中国实验方剂学杂志, 2010,16(7):105-107. DOI：

WANG Heng-he, MAO Jing-yuan, ZHANG Zhen-peng, et al. Effects of Injection on TNF-,IL-1,IL-6 in the Model Dogs with Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(7): 105-107. DOI：

摘要

目的 :考察不同剂量参麦注射液(SMI)对心衰犬血清肿瘤坏死因子α(TNF-α)

白介素1β(IL-1β)

白介素6(IL-6)的影响。方法 :将造模成功4周后的心衰犬20只随机分为模型对照组和SMI低、中、高剂量组

每组5只。模型对照组予生理盐水20 mL

低、中、高剂量组分别予参麦注射液 0.517

1.034

1.551 ml ·kg-1(生理盐水稀释至20 mL)iv qd×7。分别于给药前及给药后72 h

144 h时点取静脉血2 mL冰冻保存

用放射免疫分析法测定血清TNF-α

IL-1β

IL-6浓度。结果 :SMI低、中、高剂量组心衰犬血清TNF-α

IL-1β

IL-6水平较模型对照组下调。结论 :SMI能使心衰犬血中TNF-α

IL-1β

IL-6水平下调

并呈现一定的量效、时效关系。

Abstract

Objective: To investigate effect of different dose Shenmai Injection (SMI) on blood concentration of TNF-α

IL-1β

IL-6. Method: Twenty model dogs with heart failure (HF) were randomly divided into 4 groups: the control one(0.9% NaCl injection 20 mL iv qd ×7

n=5)and the low

middle and high dose ones of SMI (administrated by 0.517

1.034 and 1.551 mL ·kg-1

diluted to 20 mL with 0.9% NaCl injection

iv qd ×7

n=5). Blood samples (2 mL) were collected before administration and at 72 h and 144 h after that

refrigerated (at -80 ℃) to be determined for the blood concentration of TNF-α

IL-1β

IL-6 by radio-immunity assay. Results: Blood concentration of TNF-α

IL-1β

IL-6 in the different dose SMI groups was higher than that in the control one

and it showed some dose-effect relationship. Conclusions: SMI could effectively reduce blood concentration of TNF-α

IL-1β

IL-6 in the model dogs with heart failure and showed some dose-effect and time-effect relationships.

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