Objective:To compare the different sensitivity passive cutaneous anaphylaxis(PCA) caused by OVA and TCS between Sprague Dawley(SD) and Wistar rats.Method: PCA was performed by using SD and Wistar rats

and xenogenic PCA by using KM mice.OVA and TCS were taken as allergens.The diameter of dermal evan’s blue spot and the positive reaction rate were measured to discriminate severity of PCA. Result: Homologous PCA revealed that after injecting with 0.9 mg/rat TCS with or without adjuvant

two rat strains showed positive reaction.According to the diameter evan’s blue spots

the degree of response was as follows: SD rat > Wistar rat.The allergic positive reaction rate of two rat strains would be improved by adding aluminium hydroxide into OVA(5 mg/rat)

and the sensitivity of OVA of Wistar rat was more than SD rat.Xenogeneic PCA showed that after auricular intradermally injecting with OVA antiserum without aluminium hydroxide of two different rat strains

the mice demonstrated negative reaction.But the positive reaction was showed by injecting with TCS antiserum without adjuvant of SD rat.The mice showed positive reaction after auricular intradermally injecting with OVA or TCS with adjuvant of two rat strains. Conclusion: There are differences in sensitivity of OVA and TCS between SD and Wistar rat strains

and SD rat is the more sensitive of TCS than Wistar rat.Otherwise

Wistar rat is more sensitive of OVA.The allergic positive reaction rate will be improved by adding aluminium hydroxide into OVA.