逍遥散及其拆方对老年性痴呆模型小鼠学习记忆能力及抗氧化能力的影响

吴红彦; 王虎平

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逍遥散及其拆方对老年性痴呆模型小鼠学习记忆能力及抗氧化能力的影响

更新时间：2024-01-04

- 逍遥散及其拆方对老年性痴呆模型小鼠学习记忆能力及抗氧化能力的影响
- The Effect of Xiaoyao San and It's Splited Prescription on the Ability of Learning and Memory and Antioxidant of Alzheimer's Disease Model Mice
- 中国实验方剂学杂志 2009年15卷第10期页码：102-104
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- 纸质出版日期：2009
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吴红彦, 王虎平. 逍遥散及其拆方对老年性痴呆模型小鼠学习记忆能力及抗氧化能力的影响[J]. 中国实验方剂学杂志, 2009,15(10):102-104.

WU Hong-yan, WANG Hu-ping. The Effect of Xiaoyao San and It's Splited Prescription on the Ability of Learning and Memory and Antioxidant of Alzheimer's Disease Model Mice[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(10): 102-104.
吴红彦, 王虎平. 逍遥散及其拆方对老年性痴呆模型小鼠学习记忆能力及抗氧化能力的影响[J]. 中国实验方剂学杂志, 2009,15(10):102-104. DOI：

WU Hong-yan, WANG Hu-ping. The Effect of Xiaoyao San and It's Splited Prescription on the Ability of Learning and Memory and Antioxidant of Alzheimer's Disease Model Mice[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(10): 102-104. DOI：

摘要

目的:研究逍遥散对D-半乳糖(D-gal)所致老年性痴呆(AD)模型小鼠学习记忆能力及血清超氧化物歧化酶(SOD)活性、脑组织丙二醛(MDA)含量的影响

探讨逍遥散防治AD的作用及其机制。方法:采用ipD-gal复制AD小鼠模型

同时用逍遥散全方组、疏肝健脾组、疏肝养血组、健脾养血组进行对抗治疗

共42d。41d进行学习能力训练

42d进行记忆能力测试。然后取血及脑组织

测定小鼠血清SOD活性及脑组织MDA含量。结果:全方组、疏肝健脾组、疏肝养血组、健脾养血组均可提高小鼠学习记忆能力

降低潜伏时间

但以全方组最为明显;全方组、疏肝健脾组、疏肝养血组、健脾养血组皆可提高血清SOD活性

降低脑组织匀浆MDA含量

但亦以全方组最为明显。结论:逍遥散能较好的改善AD模型小鼠行为学指标

其可能与对抗自由基氧化有关。

Abstract

Objective:To investigate the effect of Xiaoyao San and it's splited prescription on the ability of learning and memory

SOD in blood serum

MDA in brain tissue of Alzheimer's Disease(AD) model mice made by D-gal and discuss the function and mechanism that Xiaoyao San defend AD.Methods:Using inject D-gal to make AD model mice while cured by Quanfang group

Shugan Jianpi group

Shugan Yangxue group

Jianpi Yangxue group of Xiaoyao San for 42 days.In the 41st day

make training of ability of learning and memory

in the 42nd day

test ability of learning and memory

then

collect blood and brain tissue to mensurate SOD in blood serum

MDA in brain tissue.Results: Quanfang group

Shugan Jianpi group

Shugan Yangxue group

Jianpi Yangxue group of Xiaoyao San could improve ability of learning and memory and reduce the latency

but Quanfang group was the most obvious.Quanfang group

Shugan Jianpi group

Shugan Yangxue group

Jianpi Yangxue group of Xiaoyao San could increase SOD in blood serum and reduce MDA in brain tissue

but Quanfang group is the most obvious too.Conclusions:Xiaoyao San can amend the behavioral index of AD model mice and that may be relate to antioxidation.

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