Objective: To investigate the therapeutic effect of total paeony glycoside on secretion of gastric juice and serum biochemical indexes for ulcer model in rat

and to reveal the mechanism. Method: Rat gastric ulcer model was established by pyloric ligation

and gastric juice was collected for rats in all groups. The gastric juice volume

total acidity and the activity of pepsin were measured. Nitric oxide (NO) content

superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in rat serum were determined. Result: Total paeony glycoside could inhibit the gastric juice volume

total acidity

the activity of pepsin in the rat model. Furthermore it could significantly increase NO content and SOD activity

and reduce the MDA content in rat serum. Conclusion: The anti-gastric ulcer mechanism of total paeony glycoside is likely achieved by promoting defense factors

and improving the bodys antioxidant capacity.