益肾法对自发性高血压大鼠肾保护作用的研究

岳竹君; 李冬华; 邹志东

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益肾法对自发性高血压大鼠肾保护作用的研究

更新时间：2024-01-04

- 益肾法对自发性高血压大鼠肾保护作用的研究
- The Research on the Protection of Kidney of Spontaneous Hypertension Rat by Kidney Improvement
- 中国实验方剂学杂志 2009年15卷第8期页码：63-65
- 作者机构：
- 作者简介：
- 基金信息：
  
  北京市教育委员会科技发展计划项目(KM200810025027)
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- 纸质出版日期：2009
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岳竹君, 李冬华, 邹志东. 益肾法对自发性高血压大鼠肾保护作用的研究[J]. 中国实验方剂学杂志, 2009,15(8):63-65.

YUE Zhu-jun, LI Dong-hua, ZOU Zhi-dong. The Research on the Protection of Kidney of Spontaneous Hypertension Rat by Kidney Improvement[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(8): 63-65.
岳竹君, 李冬华, 邹志东. 益肾法对自发性高血压大鼠肾保护作用的研究[J]. 中国实验方剂学杂志, 2009,15(8):63-65. DOI：

YUE Zhu-jun, LI Dong-hua, ZOU Zhi-dong. The Research on the Protection of Kidney of Spontaneous Hypertension Rat by Kidney Improvement[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(8): 63-65. DOI：

摘要

目的:观察益肾法对自发性高血压大鼠(SHR)肾保护作用。方法:将60只SHR随机分为模型对照组、杞菊地黄丸组、二仙汤组、杞菊地黄丸与二仙汤合方组、合方小剂量组和苯那普利组。分别观测血压动态变化情况和肾血流情况。结果:苯那普利组、杞菊地黄丸组、杞菊地黄丸与二仙汤合方组和合方小剂量组的收缩压均有显著性降低(P<0.05)

其中前3组的收缩压降低得更为明显(P<0.01)。各治疗组的肾血流高于模型对照组(P<0.01)。结论:杞菊地黄丸、杞菊地黄丸与二仙汤合方均可以降低SHR血压。杞菊地黄丸、二仙汤和杞菊地黄丸与二仙汤合方均可以提高SHR的肾血流量。

Abstract

Objective:To observe the effect of benifying the kidney on the blood pressure and blood flow in spontaneous hypertension rat(SHR).Methods:Sixty SHRs were randomly divided in groups: model control

Qiju Dihuang Wan

Erxian Tang

prescription combination

small dose prescription combination

and benazepril.The dynamic changes in blood pressure and kidney blood flow were observed.Results:The systolic pressure of benazepril

Qiju Dihuang Wan

prescription combination and small dose prescription combination was dropped significantly(P<0.05)

among which

the change in systolic pressure of the former three groups was more significant(P<0.01).The kidney blood flow of each treatment group was higher than that in the model control(P<0.01).Conclusions:Prescription combination and Qiju Dihuang Wan can decrease blood pressure in SHR.Qiju Dihuang Wan

Erxian Tang and prescription combination can promote the kidney blood flow.

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