Objective:To explore the protective mechanism of Chinese Herb-Androgrpahis paniculata Nees on the vascular disease of diabetes mellitus(DM) in rat.Methods: The DM rat model was made.Androgrpahis paniculata Nees was given to treatment group.8 weeks later

blood sample was taken to test nitric oxide(NO)and endothelin-1(ET-1).Thoracic aortic ring was employed to observe the inhibition by different concentration of Ach to constraction caused by NE.Another part of aorta was used to make slices

SP immunohistochemicae staining was employed to observe the expression of ICAM-1 and VCAM-1.Result: Androgrpahis paniculata Nees group obviously decreased plasma ET-1 and increased the level of NO comparied with Diabetes group (P<0.05)

but the parameters could not reach the level of the normal control group(P<0.05).The expression of ICAM-1 and VCAM-1 could be obviously inhibited in Androgrpahis paniculata Nees group comparied with diabetes group.But the parameters were obviously higher than normal control group(P<0.05).Conclusion: Chinses medicine Androgrpahis paniculata Nees could decrease the level of ET-1 and increase the level of NO in diabetes rats

they have the function of protecting the endothelium of vessel

and could inhibte the expression of ICAM-1 and VCAM-1

acting as the role of anti-atherosclerosis.