YAN Han1, LI Ai-yuan2, ZHAO Yi2, et al. Studies on Anti-heat-stress Activity and Its Mechanisms of Total Coumarins from Artemisia annua[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 98-100.
YAN Han1, LI Ai-yuan2, ZHAO Yi2, et al. Studies on Anti-heat-stress Activity and Its Mechanisms of Total Coumarins from Artemisia annua[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(12): 98-100.DOI:
Objective:To study the Anti-heat-stress activity and related mechanisms of total coumarins(TCs)from Artemisia annua.Methods: Heat stress rabbit model caused by high temperature and high humidity was used and rectal temperature(Tr) responses
PLA2 activity in blood and lung
circulating endothelial cells(CECs) were measured
moreover
Na+
K+-ATPase activity in brain
kedney and heart in rabbits was assayed
gasping time after decapitation in mice was observed after treatment of total coumarins(TCs) from Artemisia annua.Results: Administration of TCs reduced the rise of rectal temperature and CECs in heat stress rabbits
inhibited the activity of the PLA2 and Na+
K+-ATPase
increased the gasping time in mice.Conclusion: Coumarins are one of anti-heat-stress active fractions in Artemisia annua.