Objective: To observe the protective effect of Xingnaojing Emulsion (XNJE) on hemorrhagic shock and septic shock in rabbits. Methods: A rabbit model of hemorrhagic shock was established by bloodletting from femoral artery of rabbits; LPS of E.coli was injected to rabbits via vein to induce septic shock. The successful model rabbits were equally and randomly assigned into 5 groups: normal saline (NS) control group

low

middle and high dose of XNJE (25.7

51.4

102.75 mg·kg-1)group and positive control group (treated with Xingnaojing injection

51.4 mg·kg-1) (n=8 for each group). The antishock effect of XNJE was then observed. Results: In the hemorrhagic shock model

XNJE could obviously heighten the blood pressure

quicken the heart rate

inhibit the abnormal increase of MDA and enhance the activity of SOD in serum.Besides

in the septic shock model

XNJE could lower the death rate of rabbits

extend the survival time

heighten the blood pressure

inhibit the abnormal increase of MDA

lower the content of NO and enhance the activity of SOD in serum. Conclusion: XNJE exerts a protective effect on hemorrhagic shock and septic shock in rabbits

which could be related with the improvement of microcirculation and antioxidation.