Objective:To observe anti-inflammatory and analgesic effects of Chaihuang Compound Granule(CHCG) and its mechanism.Methods:Carrageenan-induced rat paw edema model in rat

acetic acid-induced capillary permeability increase in mouse and sodium carboxy-methylcellulose(CMC-Na)-induced leukocytes increase in mouse were used to study the anti-inflammatory effects.The analgesic effects of CHCG were tested by counting body twisting induced by acetic acid and measuring the latent period of licking hind foot with the hot plate method in mice. The content of IL-1

TNF-α

PGE2 and MDA were measured by ELISA

radio-immunity method and ultraviolet spectrophotometry respectively.Results:CHCG significantly suppressed the carrageenan-induced rat paw edema and leukocyte migration caused by CMC-Na;The content of IL-1

TNF-α

PGE2 and MDA in the inflammatory tissue extracts was significantly decreased

the capillary permeability of mice was also decreased.CHCG also improved the pain threshold of hot-plate test in mice and those injected with acetic acid.Conclusion:The anti-inflammatory and analgesic effects of CHCG are obvious and it might be associated with the decrease of IL-1

TNF-α

PGE2 and MDA.