Objective:To observe the effect of Modified Wuzi Yanzong Prescription and its components on spatial behavior in the rats with Alzheimer’s disease(AD) by Aβ25-35.Methods:The animal model of AD was established by Aβ25-35 stereotactic injection into the lateral cerebral ventricle of rats. Rats were treated with Modified Wuzi Yanzong Prescription and its components (total flavonoids and total polysaccharodes) for 15 days

Morris water maze with the video record and computer system and the spacial exploration experiment were used to assess the behavior performances of the rats. Results: Significant differences were observed between model group and Modified Wuzi Yanzong Prescription and its components treated groups (P<0.05).Compared with the model group

the escape latency and the searching distance were markedly reduced (P<0.05)

the percentage of the rats swimming time and distance in platform quadrant of the spacial experiment were markedly higher(P<0.05

P<0.01)in Modified Wuzi Yanzong Prescription and its components treated groups. Conclusion: Modified Wuzi Yanzong Prescription and its component can improve learning and memory disorders of the model rats induced by Aβ25-35.