Objective:To explore the significance of expression of MMP-2 in the vertebral artery and the intervenient effects of Compound Chuanji Pills on it.Methods: Forty rabbits were randomly divided into four groups: the normal group

the model group

the Jingfukang(JFK) Group and the Chuanji Pills(CJP)group.The method of injecting sclerosing agent was used to induce the vertebral artery type of cervical spondylosis in rabbits.Four weeks later

the model group

JFK group and CJP group were treated with sodium chloride

suspension of JFK or suspension of CJP respectivily by intragastric administration.After four weeks of therapy

the pulsatility index of the vertebral artery

the plasma viscosity

the blood viscosity and the expression of matrix metalloproteinase-2(MMP-2) in the vertebral artery were detected.Results: The pulsatility index

plasma viscosity

blood viscosity and expression of MMP-2 were significantly higher in the model group than that of normal group(P<0.05);compared with the normal group and the model group

the pulsatility index of the vertebral artery

plasma viscosity

blood viscosity and expression of MMP-2 decreased remarkably in the CJP group(P<0.05).Conclusion: One of the mechanism of CJP in treating of cervical spondylosis might partially inhibit the expression of MMP-2 in the vertebral artery.