Objective:To evaluate the effects of pre-treatment of Chinese Medicine with functions of cooling and promoting blood circulation on the pathological changes of rats with radio-pulmonary lesion

and validate its control efficiency on the TCM syndrome. Methods:160 female wistar rats were divided randomly into the model group(A)

the Chinese medicine group(B)

the Chinese medicine control group(C) and the blank control group(D) with 40 rats in each group. The rats in group A and B received X-ray radiation at 3Gy×2/W×(3～5W). 8 rats randomly selected from each group were sacrificed at the end of 3th

5th

8th

12th

26th week respectively. The developmental characteristics of TCM were analyzed in radio-pulmonary lesion during exposure by dynamic examination and comparison. Results:In group A

in early stage of radiation exposure

signs and symptoms as "dominance of heat in the interior" syndrome were observed and signs as "collaterals damaged by heat" syndrome were observed by microscope; in later stage of radiation exposure

signs and symptoms as "emphraxis of collaterals by blood stasis" syndrome were observed by microscope. All the signs and symptoms in group B showed less serious than group A; and no abnormal changes were observed in group C and D. Conclusion:Pre-treatment with Chinese medicine of cooling and promoting blood can effectively prevent radio-pulmonary lesion and control the evolution of TCM syndrome. Symptomatological and developmental characteristics of radiation-induced lung injury can be revealed in animal experiments at each levels. The study provides theoretical and experimental basis for pre-treatment with Chinese medicine of cooling and promoting blood to prevent and control radio-pulmonary lesion.