Objective:By observed the effection in volatile oil of San Ao Tang and its Serial decoctions on ovalbumin induced asthma model in guinea pig

their action on asthma is preliminary compared. Methods:Guinea pigs were sensitized intraperitoneally with 10% ovalbumin(OVA). Two weeks after sensitization they were challenged with 1% OVA aerosol. The delitescence

scores on ethology

percentages of eosinophils(EOS) in bronchoalveolar lavage fluid(BALF)

levels of interleukin(IL)-4

IL-5 and interferon gamma(IFN-γ) in serum were detected by enzyme-linked immunoassay(ELISA). Results:Volatile oil of San Ao Tang DecoctionⅠand Ⅱcould improve the percentages of EOS in BALF

IL-4

5 and IFN-γ in serum

and scores of lung tissue pathology. Volatile oil of San Ao Tang Decoction Ⅲ can significantly improve the percentages of EOS in BALF and pathological scores of lung tissue(P<0.01). Volatile oil of San Ao Tang can improve the percentages of EOS in BALF

and IL-4

IFN-γ in serum. Conclusion:Volatile oil of San Ao Tang DecoctionⅠandⅡcould regulate the immune function of the body

in aspects of regulating the cytokines

suppressing the inflammation in respiratory

and may directly inhibit the role of tracheal smooth muscle spasm

reaching its role of suppression in asthma symptoms. Volatile oil of San Ao Tang Decoction Ⅲ has the significant effects in inhibiting the production and aggregation of the EOS in respiratory.