WANG Qiu-jing1, LIU Fen1, LIU Jie1, et al. Effects of Panaxdiols Saponin on Hemorheological Parameters and PGF,TXB in Rat Model of Acute Blood Stasis[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(5): 52-54.
WANG Qiu-jing1, LIU Fen1, LIU Jie1, et al. Effects of Panaxdiols Saponin on Hemorheological Parameters and PGF,TXB in Rat Model of Acute Blood Stasis[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(5): 52-54.DOI:
Objective:To investigate the effects of Panaxdiols Saponin (PDS)on hemorheology and PGF1a
TXB2 in rat model of acute blood stasis. Methods:Sixty rats were divided at random into six groups:normal control
model control
positive control
5 mg·kg-1 PDS
10 mg·kg-1 PDS and 20 mg·kg-1 PDS groups.The blood stasis model was made by adrenaline administration and coldness stimulation.The effects of PDS(iv.) on hemorheological parameters and PGF1a
TXB2 in rat model were observed. Results:PDS can decrease the whole blood viscosity and TXB2 in heart and lung
increase PGF1a in heart and lung. Conclusions:PDS improves significantly abnormal changes of hemorheological parameters in rat model of acute blood stasis.PDS can adjust the balance between PGF1a and TXB2.