Objective: To observe the influence of Shi-re-bi Tablet on T lymphocyte and cytokine network in the adjuvant-induced arthritis SD rats.Methods: Induce the model of adjuvant arthritis in SD rats through the immunization of heat-killed Mycobacterium Tuberculosis H37RA(Mtb).Measure the level of TNF-α and T lymphocyte subsets in the experimental animal's peripheral blood by ELISA.At the same time

measure the level of IL-1β

IL-6

IL-10 and VEGF in the synovial tissues of ankle joint in the rheumatoid arthritis rats.Results: Compared with the model group

Shi-re-bi Tablet could raise the level of CD8+ T lymphocyte(P<0.05) and reduce the ratio of CD4+/CD8+(P<0.05)

proinflammatory TNF-α

IL-1β and IL-6(P<0.01)

at the same time

the content of VEGF is reduced(P<0.01) and the level of anti-inflammatory IL-10 is raised(P<0.01).Conclusions: Shi-re-bi Tablet can regulate the balance of T lymphocyte and cytokine network

and thus may be its mechanism for treatment of rheumatoid arthritis.