Objective:To investigate the advantages of three kinds of experiment design methods in optimizing the preparation of dispersible tablet.Method:The disintegration time was chosen as the evaluation index of dispersible tablet.The optimal formulation of Yuanhuzhitong Dispersible Table including the extract powder

fillers and disintegrants were established by the mixture design

the central composite design and orthogonal design.Results:The dispersible tablet optimized by the three experiment design methods met the requirements of dispersible tablet.The three experiment design methods have their owner's advantages

but the mixture design is more suitable for optimizing the formulation than other experiment design methods.Conclusion:The mixture design can decrease the times of experiment in optimizing formulation of dispersible tablet

and the result is intuitive and reliable.The mixure design deserves promotion in the research of traditional Chinese medicine.