The eighteen incompatible medicaments and nineteen medicaments of mutual restraint have been tought of traditional prohibited combination in long time

but people are unable to agree upon interrelated theories and can not reach an accordant consideration.From their origins and different comprehension of present TCM

this paper sum up and analyze previous experimental results in toxicology

pharmacology

chemistry and informatics so as to comprehend the scientific significance of the eighteen incompatible medicaments and nineteen medicaments of mutual restraint.We suggest that every drug pair has its own characteristic

one or several pairs can not typif the whole Eighteen Incompatible medicaments and nineteen medicaments of mutual restraint.Therefore the accurate modern understanding can only be reached until a systematic reseach on the whole drug pairs is done.