Objective:To optimize the preparation technique of Liuweidihuang Dropping Core Pills.Methods:The preparation procedure of Dropping Core Pills was divided into two steps.First

the dropping pills were prepared with the extracts of Cortex Moutan and Rhizoma Alismatis

meanwhile

the conditions were optimized using combination index by single factor experiment and orthogonal experiment.Second

the dropping pills as mother nucleus were enveloped in the mixed materials and adjuvants.Finally

Liuweidihuang Dropping Core Pills were produced after forming、poudrage、arescent

、selecting、coating.Results: The optimized preparation conditions are as follow: PEG10000+PEG6000(1∶10) is optimal bases and bases: drugs≥2∶1

(10 ℃) simethicone is condensate

Dropping temperature is(85 ℃) and dropping distance is 5 cm.The optimal adhesive is glycerin:95% ethanol=1∶9.Conclusion: The method of Liuweidihuang Dropping Core Pills preparation is reliable.The preparation procedure is controllable and easier to disintegrati.It is suitable for Traditional Chinese Medicine including liposoluble

evaporability components.It is a good method which can prevent loss of content.