Objective: To evaluate the effects of Shaofu Zhuyu decoction

prescription minus Puhuang -Wulingzhi drug pair and Puhuang -Wulingzhi drug pair on hemorheological parameters in rat mode of acute blood stasis

and the influence on platelet aggregation and clotting time in vitro. Method : Rat mode of acute blood stasis was used to evaluate the Changes in hemorheology

the function of blood coagulation and ovarian. The platelet aggregation was tested with Born's method and thrombin time (TT) method in vitro was established to determine the clotting time. Result : The results stated that Shaofu Zhuyu decoction showed significant improvements in the hemorheological indexes of rats in the model of blood stasis and regulation for the secret function of rat ovarian. Meanwhile

the result of vitro assay showed that Shaofu Zhuyu Decoction had significantly inhibitory effects on the platelet aggregation and prolonged clotting time. The effects of Puhuang -Wulingzhi drug pairare superior to the group of prescription minus Puhuang -Wulingzhi drug pair on reducing whole blood viscosity

plasma viscosity and extending clotting time in vitro. Conclusion: Shaofu Zhuyu decoction can improve the indexes of hemorheology in rat model of blood stasis

and showed significant inhibitory effect on platelet aggregation and clotting time. Furthermore

Puhuang -Wulingzhi drug pair plays the major role in the biological effect for the whole prescription.