Objective: The technology of enriching phenolic acids was researched from Lycopus lucidus Turcz by macroporods resins. Method: The peak areas of protocatechualdehyde

caffeic acid and rosmarinic acid were compared from the ten kinds of macroporous resins’desorbED solutions under the same HPLC condition to determine the kind of macroporous resins.The contents of protocatechualdehyde

caffeic acid and rosmarinic acid were chosen as assessment index to decide the concentration of ethanol. Result: The two kinds of macroporous resins

HPD-600 and AB-8 from Hebei province were optimized. The adsorption resin of HPD-600 was appropriate to enrich protocatechualdehyde and the eluant was 50% ethanol; the adsorption resin of HPD-600 was appropriate to enrich caffeic acid and the eluant was 95% ethanol; the adsorption resin of AB-8 was appropriate to enrich rosmarinic acid and the eluant was 95% ethanol. Conclusion: This experiencelaid a foundation for the enrichment technology of the phenolic acids from Herba Lycopi

it provided the key technology for the further research of Herba Lycopi’s consititutions.