WANG Liang, LONG Zi-jiang, SHI Hui, et al. Experimental Study on the Treatment of Xinkang Injection on Model Rats with Acute Myocardial Ischemia[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(1): 69-71.
WANG Liang, LONG Zi-jiang, SHI Hui, et al. Experimental Study on the Treatment of Xinkang Injection on Model Rats with Acute Myocardial Ischemia[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(1): 69-71.DOI:
Objective:To study the therapeutic effect and mechanism of Xinkang injection on model rats with acute myocardial ischemia.Method: Model rats with acute myocardial ischemia were prepared by coronary artery ligation.The influences on the content of creatine kinase(CK)
lactate dehydrogenase(LDH)
malonaldehyde(MDA)
Superoxide dismutase(SOD) and ADP-induced platelet aggregation rate were observed.Results:Xinkang injection significantly reduced the content of CK
MDA
LDH in serum of model rats with acute myocardial ischemia.Xinkang injection significantly improved the content of SOD in serum of model rats;Xinkang injection reduced the rate of platelet aggregation of model rats.Conclusion: Xinkang injection can reduce the content of CK
MDA
LDH
improve the content of SOD
and inhibit the rate of platelet aggregation.Xinkang injection has a preventive and therapeutic effect on model rats with acute myocardial ischemia prepared by coronary artery ligation.