鼠妇乙醇提取物镇痛抗炎作用及化学成分研究

李宁; 匡岩巍; 陈明友; 张庆林

您当前的位置：

首页 >

文章列表页 >

鼠妇乙醇提取物镇痛抗炎作用及化学成分研究

更新时间：2024-01-04

- 鼠妇乙醇提取物镇痛抗炎作用及化学成分研究
- Analgesic,Anti-inflammatory Effects and Chemical Constituents of Ethanol Extract from Shufu
- 中国实验方剂学杂志 2008年14卷第11期页码：74-76
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：2008
- 稿件说明：
移动端阅览
李宁, 匡岩巍, 陈明友, 等. 鼠妇乙醇提取物镇痛抗炎作用及化学成分研究[J]. 中国实验方剂学杂志, 2008,14(11):74-76.

LI Ning, KUANG Yan-wei, CHEN Ming-you, et al. Analgesic,Anti-inflammatory Effects and Chemical Constituents of Ethanol Extract from Shufu[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 74-76.
李宁, 匡岩巍, 陈明友, 等. 鼠妇乙醇提取物镇痛抗炎作用及化学成分研究[J]. 中国实验方剂学杂志, 2008,14(11):74-76. DOI：

LI Ning, KUANG Yan-wei, CHEN Ming-you, et al. Analgesic,Anti-inflammatory Effects and Chemical Constituents of Ethanol Extract from Shufu[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 74-76. DOI：

摘要

目的:研究鼠妇乙醇提取物的镇痛和抗炎作用

并对其化学成分进行初步分离鉴定。方法:通过小鼠醋酸扭体法镇痛实验和环氧化酶抑制剂体外检测

研究鼠妇乙醇提取物的镇痛抗炎作用;通过色谱方法对鼠妇乙醇提取物化学成分进行分离纯化

并用各种理化及波谱技术鉴定其化学结构。结果:鼠妇乙醇提取物能明显延缓小鼠开始扭体反应的时间

减少小鼠的扭体次数;鼠妇乙醇提取物对环氧化酶-1(COX-1)、环氧化酶-2(COX-2)均有抑制作用;从鼠妇乙醇提取物中分离得到7个化合物

分别为β-谷甾醇、5-烯-3β-胆甾醇、麦角甾醇、7α-羟基胆甾醇、7β-羟基胆甾醇、正十八酸、顺式9-十八烯酸。结论:鼠妇乙醇提取物具有明显的镇痛和抗炎作用。

Abstract

Objective:To investigate the analgesic

anti-inflammatory effects and the chemical constituents of alcohol extract of Shufu.(AVA) Methods:The analgesic effect of AVA were tested by counting body twisting induced by HAc in mice and the anti-inflammatory effects of AVA were tested by using the Colorimetric COX Inhibitor Screening Assay.The constituents were isolated and purified by chromatographic methods.Their structures were identified by physicochemical properties and spectral analysis.Results:AVA could delay the writhing time and reduce the writhing times in mice. AVA could inhibit the COX-1 and COX-2 enzymes activitres.Seven compounds were isolated and the stuctures were identified as β-Sitosterol

cholesterol

ergosterol

7-OH cholesterol

7β-OH cholesterol

octadecanoic acid and 9-octadecenoic acid.Conclusions:AVA has obvious analgesic and anti-inflammatory effects.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

紫河车化学成分和药理作用研究进展

基于脾胃虚寒大鼠的厚朴温中汤体内外成分鉴定及药代动力学分析

老鹳草属药用植物鞣质成分及防治阿尔茨海默病研究进展

桑寄生族植物化学成分及药理作用研究进展

经典名方达原饮化学成分的UPLC-Q-Exactive Orbitrap MS快速表征