半佛纳米微丸抗炎药效学及急性毒性实验研究

曹有军; 卜平; 孔桂美; 杨金龙; 钟安

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半佛纳米微丸抗炎药效学及急性毒性实验研究

更新时间：2024-01-04

- 半佛纳米微丸抗炎药效学及急性毒性实验研究
- Experimental Study on Pharmacodynamic Action of Anti-inflammation of BanFo Nanometer Buccal Tablets and Its Acute Toxicity
- 中国实验方剂学杂志 2009年15卷第1期页码：64-65
- 作者机构：
- 作者简介：
- 基金信息：
  
  江苏省科技厅高新技术项目(BG200606)
- DOI：
  中图分类号：
- 纸质出版日期：2009
- 稿件说明：
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曹有军, 卜平, 孔桂美, 等. 半佛纳米微丸抗炎药效学及急性毒性实验研究[J]. 中国实验方剂学杂志, 2009,15(1):64-65.

CAO You-jun, BU Ping, KONG Gui-mei, et al. Experimental Study on Pharmacodynamic Action of Anti-inflammation of BanFo Nanometer Buccal Tablets and Its Acute Toxicity[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(1): 64-65.
曹有军, 卜平, 孔桂美, 等. 半佛纳米微丸抗炎药效学及急性毒性实验研究[J]. 中国实验方剂学杂志, 2009,15(1):64-65. DOI：

CAO You-jun, BU Ping, KONG Gui-mei, et al. Experimental Study on Pharmacodynamic Action of Anti-inflammation of BanFo Nanometer Buccal Tablets and Its Acute Toxicity[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(1): 64-65. DOI：

摘要

目的:探讨半佛纳米微丸抗炎的作用机制。方法:检测半佛纳米微丸对巴豆油诱发小鼠耳廓肿胀的影响;对角叉菜胶致大鼠足跖肿胀的影响及对大鼠棉球肉芽肿增生的影响;测小鼠半数致死量及一日最大耐受量。结果:半佛纳米微丸对巴豆油诱发的小鼠耳廓肿胀、角叉菜胶致大鼠足跖肿胀及大鼠棉球肉芽肿增生均有抑制作用

有抗急性炎症作用;一日最大耐受量相当于临床用量的112倍

提示临床用量在安全范围。结论:半佛纳米微丸有抗炎作用

临床用量在安全范围。

Abstract

Objective:To explore BanFo Nanometer Buccal Tablets's pharmacodynamic action of anti-inflammation

its acute toxicity and tolerance test on mice.Methods:The mixture's pharmacodynamic action was measured by observing its effect on croton oil-induced ear swelling in mice;hind raws swelling in rats induced by carrageen and the weight of granulation in rats induced by tampon.The max dosage that mice could tolerate was recorded.Results: BanFo Nanometer Buccal Tablets can markedly inhibit the inflammatory on croton oil-induced ear swelling in mice;hind raws swelling in rats induced by carrageen and the weight of granulation in rats induced by tampon.And the daily maximum tolerant dosage was equal to 112 times of clinical routine

which provided the proof of its safty.Conclusion: BanFo Nanometer Buccal Tablets has effect of antiinflammation which agrees with its clinical effect.The clinical dosage of the tablets is within the safty range.

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