ZHOU Min1, DONG Na1, HAN Yu-sheng1, et al. Influence of Biqing Capsule on IL-12 and COX-2 Expression in Mouse with Acute Gouty Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 53-54.
ZHOU Min1, DONG Na1, HAN Yu-sheng1, et al. Influence of Biqing Capsule on IL-12 and COX-2 Expression in Mouse with Acute Gouty Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(11): 53-54.DOI:
Objective:By uric acid sodium(MUS)-induced acute gouty arthritis model
to observe Biqing Capsule treatment for acute gouty arthritis.Methods: The IL-12 content in joint fluid of ankle was measured by ELISA method.Mouse ankle COX-2 expression was determined by immunohistochemical methods.Results:Biqing Capsule obviously decreased ankle IL-12 levels and restrained rat ankle COX-2 expression.It indicated that Biqing Capsule for acute gouty arthritis had some anti-inflammatory effects.Conclusion: The Biqing Capsule's anti-inflammation and analgesia mechanism may be related to decreased ankle IL-12 level and restrained ankle COX-2 expression.