Objective:To investigate the anti-inflammatory mechanism of total glucosides of Cape Jasmine(TGCJ) on rats with adjuvant arthritis.Methods: Rats were randomly divided into the normal group

the model group

the GTW group

and the TGCJ groups of small

medium

large dosages(20

40

80 mg·kg-1).Except for the normal group

animals were modeled to form adjuvant-induced arthritis with Freund's complete adjuvant.The arthritis index(AI) and the swelling degree of paws were recorded

and the activity of IL-1β

TNF-α and the levels of NO

NOS and PGE2 in joint synovium of secondary arthritis were determined.Results: Compared with the normal group

the levels of NO

NOS

PGE2 and the activity of IL-1β and TNF-α in joint synovium of secondary arthritis were increased significantly in the model group.Compared with the model group

TGCJ showed a dramatic inhibitory effect on secondary reaction of adjuvant arthritis

and the levels of NO

NOS

PGE2 and the activity of IL-1β and TNF-α in joint synovium of secondary arthritis were significantly decreased.Conclusions: TGCJ has a remarkable treatment effect on arthritis.Inhibiting the activity of cytokines and decreasing the level of inflammation media in inflammatory region may be involved in the mechanisms of the therapeutic effects of TGCJ.