侯氏黑散对大鼠大脑中动脉闭塞模型缺血脑组织Na-K-ATP酶及一氧化氮合酶活性的影响

张秋霞; 赵晖

您当前的位置：

首页 >

文章列表页 >

侯氏黑散对大鼠大脑中动脉闭塞模型缺血脑组织Na-K-ATP酶及一氧化氮合酶活性的影响

更新时间：2024-01-04

- 侯氏黑散对大鼠大脑中动脉闭塞模型缺血脑组织Na-K-ATP酶及一氧化氮合酶活性的影响
- The Effects of Houshiheisan on Activeness of Na-K-ATPase and NOS in Cerebral Tissue of Middle Cerebral Artery Occlusion Model in Rat
- 中国实验方剂学杂志 2008年14卷第7期页码：31-33
- 作者机构：
- 作者简介：
- 基金信息：
  
  北京市教育委员会科技基金(KM2003100025099)
- DOI：
  中图分类号：
- 纸质出版日期：2008
- 稿件说明：
移动端阅览
张秋霞, 赵晖. 侯氏黑散对大鼠大脑中动脉闭塞模型缺血脑组织Na-K-ATP酶及一氧化氮合酶活性的影响[J]. 中国实验方剂学杂志, 2008,14(7):31-33.

ZHANG Qiu-xia, ZHAO Hui. The Effects of Houshiheisan on Activeness of Na-K-ATPase and NOS in Cerebral Tissue of Middle Cerebral Artery Occlusion Model in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(7): 31-33.
张秋霞, 赵晖. 侯氏黑散对大鼠大脑中动脉闭塞模型缺血脑组织Na-K-ATP酶及一氧化氮合酶活性的影响[J]. 中国实验方剂学杂志, 2008,14(7):31-33. DOI：

ZHANG Qiu-xia, ZHAO Hui. The Effects of Houshiheisan on Activeness of Na-K-ATPase and NOS in Cerebral Tissue of Middle Cerebral Artery Occlusion Model in Rat[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(7): 31-33. DOI：

摘要

目的:观察侯氏黑散对大脑中动脉闭塞模型大鼠缺血脑组织Na+-K+-ATP酶、一氧化氮合酶(NOS)活性以及诱导型一氧化氮合酶(iNOS)的影响。方法:采用线栓法复制大鼠大脑中动脉闭塞模型

利用比色法观察侯氏黑散对大鼠缺血脑组织Na+-K+-ATP酶、NOS、iNOS活性的影响。结果:与模型组比较

侯氏黑散组大

中剂量组缺血脑组织Na+-K+-ATP酶活性显著提高(P<0.05)。侯氏黑散大

中

小剂量组NOS、iNOS的活性明显降低(P<0.05)。结论:侯氏黑散可能是通过提高脑组织Na+-K+-ATP酶活性和降低NOS、iNOS的活性保护和修复缺血性脑损伤。

Abstract

Objective:To observe the effects of Houshiheisan on activities of Na+-K+-ATPase

NOS and iNOS in cerebral tissue of middle cerebral artery occlusion model in rat.Methods: Middle cerebral artery occlusion model was replicated by string ligation.Using behavioral test

the neurological deficiency of each group after operation was evaluated.The change in Na+-K+-ATPase

NOS and iNOS was detected by colorimetry.We observed the effects of Houshiheisan on activities of Na+-K+-ATPase

NOS and iNOS in cerebral tissue of middle cerebral artery occlusion model.Results: In comparison with model group

Houshiheisan can increase the activities of Na+-K+-ATPase in ischemic tissue of brain with the large or middle dose.Moreover Houshiheisan decreased activities of NOS and iNOS in ischemic tissue of brain with the large

middle and lower dose.Conclusions:Houshiheisan may increase the activities of Na+-K+-ATPase and decrease activities of NOS and iNOS for protecting the ischemia tissue.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

辛芍组方效应成分在正常和脑缺血再灌注损伤大鼠肝微粒体中的酶促反应动力学分析

三七复合有效成分对恒河猴细菌感染性子宫出血模型内膜组织一氧化氮及一氧化氮合酶的影响

鬼针草总黄酮对-GalN致急性肝损伤小鼠的保护作用

竹节参醇提物对LPS诱导RAW264.7细胞炎症的保护作用