Objective:To investigate the effects of Jiaweibiejia(JWBJ) Pills on the IgG in serum of hepatic fibrosis rats(HFR).Methods:The rats were randomly divided into control group

model groups

colchine group and Ganpikang group.The model groups were treated or pre-treated with low-dose

middle-dose or high-dose of JWBJ.The serum IgG taken from each group was tested with immunodiffusion method.Results:In the HFR induced by HSA

the level of serum IgG was significantly decreased when treated with the high-dose JWBJ or pre-treated with JWBJ for both middle-dose and high-dose(P<0.05) compared with the matched model group respectively.In the HFR induced by CCl4

only the high-dose of JWBJ pre-treated group significantly decreased the level of serum IgG(P<0.05).Conclusions:JWBJ can decrease the serum IgG in HFR induced by CCl4 or HAS.It sugguest that JWBJ can modulate the immune function and should be considerd in the therapeutic of hepatic fibrosis.