Objective:To study the role and mechanism of Qingnao Xuanqiao Dropping Pill(QNXQDP) on acute cerebral ischemia.Methods: Adopting the middle cerebral artery occlusion(MCAO)model induced by inserting a monofilament suture

the infarct size

the content of LD

MDA and the activity of GSH and LDH

SOD in brain homogenate were observed.We determined the expression of ICAM-1 in the brain influenced by QNXQDP by immunohistochemical staining method.Results:QNXQDP 180 mg·kg-1

90 mg·kg-1 can significantly reduce the scope of the rat MCAO cerebral infarction;180 mg·kg-1 could significantly reduce the content of LD in the rat brain homogenate of the troubled side

180 mg·kg-1

90 mg·kg-1

45 mg·kg-1 can significantly reduce the increased LDH activity

enhance the activity of SOD and reduce the content of MDA in the side of the brain surgery

180 mg·kg-1

90 mg·kg-1 can significantly improve the content of GSH in the side of the brain operation;180 mg·kg-1 can significantly reduce the integral optical density of ICAM1 in positive expression.Conclusion:QNXQDP has protective effect on cerebral ischemia.The possible mechanism may be by reducing acid poisoning

inhibiting free radical damage and restoring the balance between free radical metabolism;inhibiting the expression of adhesion molecules

reducing the inflammatory response induced by ischemic reperfusion.