Objective:To investigate the protective effects of Anxin Granules on the experimental myocardial injury in rabbits.Methods: Fifty-eight rabbits were randomly divided into 6 groups: the control group

the model group

Anxin Granules small(0.45 g·kg-1·d-1)

middle(0.9 g·kg-1·d-1)

big(1.8 g·kg-1·d-1)group and propranolol group.Each group was intragastric administration in the first three days

each group except the control group was drop with isoprenaline after one hour of intragastric administration in the middle three days

each group was intragastric administration in the last three days

the animals were sacrificed by bleeding from carotid artery at the end of the experiment.The blood was sampled from the ear artery.The lactic dehydrogenase(LDH) and aspartate aminotransferase(AST) in the plasma were detected;then the heart were solidified

embedded

sectioned

stained with HE and graded pathologically.Result: The plasmatic activities of LDH in the model group were significantly higher than those in the control group(P<0.01 or P<0.01);the degree of myocardial pathological damage in the model group was significantly higher than that in the control group(P<0.01)

while the degree of damage in the protection group was lower than that in the model group(P<0.01).Conclusion: Anxin granules can protect myocardial injury in the rabbits.