Objective:To study the effects of Liangxuehuoxue Formula on the the expression of multiple adhesion molecules in treating a cecal ligation and puncture(CLP) rat septic model.Methods:Using a sepsis model induced by CLP

the septic rats were treated with 3 different doses of liquid extract of Liangxuehuoxue Formula for 72 hours.The expressions of CD11b

CD31

CD54 and CD62L in leucocytes of circulating blood and bronchoalveolar lavage fluid(BALF) were determined by flowcytometry.Myeloperoxidase(MPO) activity of lung

liver and intestinal tissues were examined.Results:The 72 h mortality of model group was 70% and the expressions of CD11b

CD31

CD54 and CD62L in leucocytes of circulating blood and BALF and MPO of lung

liver and intestinal tissues in model group were all increased significantly compared with sham operation group.The high dose of Liangxuehuoxue Formula decreased the 72 h mortality to 20%

significantly lower than that of model group.The high and middle doses of Liangxuehuoxue Formula reduced the CD11b

CD31

CD54 and CD62L expressions in leucocytes of circulating blood and BALF and MPO of lung

liver and intestinal tissues significantly.Conclusions:The high expressions of adhesion molecules and their adhesive effects on the endothelium play an important role in the pathological process of multiple organ dysfumctions in sepsis and the Liangxuehuoxue Formula has therapeutic effects on septic model by reducing the high expressions of multiple adhesion molecules.