Objective:To observe effect of Zhenwu decoction on renal function in the chronic renal failure(CRF) rats.Methods:Rat model of Chronic renal failure was established by adenine administration after unilateral nephrectomy.Zhenwu decoction group gavaged by Zhenwu decoction for 28 days.Body weight

24 h urine and 24 h urinary protein were measured in every seven days.After 4 weeks

blood samples were taken from the femoral artery.RBC

Hb

serum creatinine

blood urea nitrogen

serum calcium and phosphorus were detected. Results:Zhenwu decoction group better than model group in 24h urinary protein

serum creatinine

blood urea nitrogen

serum phosphorus

Serum Calcium.Conclusions:Zhenwu decoction has a protective effect on renal function in rats with chronic renal failure induced by adenine after unilateral nephrectomy.