Objective:To do some comparative study on anti-inflammatory

antipyretic and immunomodulation effects between extracts from cultural and wild Radix Scutellariae.Methods: The anti-inflammatory action was assessed by croton oil-induced ear edema in mice and HAc-induced peritoneal capillary permeability in mice.The antipyretic action was monitored by dried yeast-induced fever in rats.The effect of nonspecific immunity function was detected through the experiment of the clearance rate of charcoal particles in mice.Results: Both extracts from cultural and wild Radix Scutellariae significantly improved the ear edema in mice and inhibited the phlogistic infiltration in mice;The fever induced by dried yeast was reduced by both extracts of Radix Scutellariae;Both extracts of Radix Scutellariae can obviously promote the carbon clearance ability in mice.Conclusion:There is no significant difference in anti-inflammatory

antipyretic and immunomodulation effects between extracts from cultural and wild Radix Scutellariae.The results provide experimental basis for Cultural Scutellariae to replace wild Scutellariae in clinical use.