LI Zhen-kun1, 3, CHEN Jian-xin2, et al. Association between Rhizoma Chuanxiong Constituents Combinations and Vasodilatation Activity Based on Least Angle Regression Algorithm[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(3): 24-26.
LI Zhen-kun1, 3, CHEN Jian-xin2, et al. Association between Rhizoma Chuanxiong Constituents Combinations and Vasodilatation Activity Based on Least Angle Regression Algorithm[J]. Chinese journal of experimental traditional medical formulae, 2009, 15(3): 24-26.DOI:
Objective: To investigate the method of constituent-activity relationship suitable for Chinese herbs.Methods and Results: Rhizoma chuanxiong is set as a paradigm
based on the least angle regression algorithm
we find the association between the vasodilatation activity and the different concentration combination of ferulic acid
butylphthalide and ligustilide
according to the scheme of Uniform Experimental DesignEfficacy Experiment——mathematical modeling(model validation).We also optimize the different concentration combination of the three constituents.Conclusion: Least angle regression algorithm is an effective method for research of constituent-activity relationship of Chinese herbs.