Objective:To investigate the anti-inflammatory and analgesic actions of Zhiyanxiao Granule.Methods:The increased permeability of abdominal capillaries induced by acetic acid in mice

the inflammation induced by dimethyl benzene on mice ear and the granuloma formation induced by cotton pellet in rats were performed to observe the anti-inflammatory action of Zhiyanxiao Granule.Pain induced by acetic acid and hot-plate procedure in mice were performed to observe the analgesic action of Zhiyanxiao Granule.Results:Zhiyanxiao Granule could significantly decrease effusion of Evans blue from abdominal capillaries induced by acetic acid in mice

the swelling degree of mice ear induced by dimethyl benzene and the weight of granuloma induced by cotton pellet.It also retained response time and reduced the number of writhing in mice caused by acetic acid

as well as decreased the pain score of mice in hot-plate test.Conclusion: Zhiyanxiao Granule has the anti-inflammatory and analgesic actions

and may have good therapeutic effect on haemorrhoids.