Objective:To study the effect of Wang Laoji Liangcha(WLJ) on plasma lipids metabolism and oxidative situation in restraint mice.Methods:The female mice were randomly divided into normal control group

stress control group

positive control groupe

two WLJ groups(125 mg·kg-1 and 500 mg·kg-1).After intravenously injected Intralipids into the 20 h restrained mice

the content of plasma lipid and lipoprotein lipase(LPL) activity were determined.The oxidative situation and antioxidtive capacity of plasma were measured.Results:Compared with the control groups

WLJ accelerated the basic metabolism of plasma lipids

improved the lipoprotein lipase(LPL) activity in restraint mice.And it also decreased the level of MDA and increased the antioxidant capacity of plasma(ORAC).Conclusion:WLJ improves the lipid metabolic dysfunction in restraint mice

and the mechanism might be related to the amelioration of oxidative situation in plasma.