龙胆泻肝汤配伍减毒的化学研究

许刚; 谢鸣

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龙胆泻肝汤配伍减毒的化学研究

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- 龙胆泻肝汤配伍减毒的化学研究
- Chemical Analysis on Attenuation Mechanism of the Compound Compatibility of Longdan Xiegan Decoction
- 中国实验方剂学杂志 2008年14卷第5期页码：20-22
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- 纸质出版日期：2008
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许刚, 谢鸣. 龙胆泻肝汤配伍减毒的化学研究[J]. 中国实验方剂学杂志, 2008,14(5):20-22.

XU Gang, Xie Ming. Chemical Analysis on Attenuation Mechanism of the Compound Compatibility of Longdan Xiegan Decoction[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(5): 20-22.
许刚, 谢鸣. 龙胆泻肝汤配伍减毒的化学研究[J]. 中国实验方剂学杂志, 2008,14(5):20-22. DOI：

XU Gang, Xie Ming. Chemical Analysis on Attenuation Mechanism of the Compound Compatibility of Longdan Xiegan Decoction[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(5): 20-22. DOI：

摘要

目的:探讨含关木通的龙胆泻肝汤及其相关配伍制剂的减毒机制。方法:采用HPLC法测定关木通及龙胆泻肝汤相关配伍制剂中马兜铃酸A含量。结果:关木通甲醇提取液;关木通水提取液;龙胆泻肝汤;去除当归、生地、甘草的龙胆泻肝汤中马兜铃酸A含量分别为0.1936

0.0627

0.0324

0.0454mg·mL-1。结论:龙胆泻肝汤全方中马兜铃酸A含量明显低于单味关木通和去除当归、生地、甘草的龙胆泻肝汤方

提示龙胆泻肝汤全方相对较低的肾毒性与其水提过程中马兜铃酸A溶出减少有关

方中佐使药味当归、生地、甘草的配伍可能起重要作用。

Abstract

Objective:To investigate the attenuation mechanism of Longdan Xiegan Decoction and other relevant prescriptions containing Aristolochia manshriensis Kom.Methods:To determine the content of aristolochiae acid A in Aristolochia manshriensis Kom and the relevant prescriptions of Longdan Xiegan Decoction with different components by the method of HPLC.Results:In the extract of Aristolochia manshriensis Kom by methanol

by water

Longdan Xiegan Decoction and Longdan Xiegan Decoction without Angelica sinensis

Rehmannia glutinosa Libosch and Glycyrrhizae uralensis

the content of aristolochiae acid A is 0.193 6

0.062 7

0.032 4

0.045 4 mg·mL-1 accordingly.Conclusion:The content of aristolochiae acid A in Longdan Xiegan Decoction is significantly lower than that of the extract of Aristolochia manshriensis Kom and Longdan Xiegan Decoction without Angelica sinensis

Rehmannia glutinosa Libosch and Glycyrrhizae uralensis.The results indicate that the lower nephrotoxicity of Longdan Xiegan Decoction is likely due to the decrease of aristolochiae acid A in the extract by water

and the compatibility of Angelica sinensis

Rehmannia glutinosa Libosch and Glycyrrhizae uralensis in Longdan Xiegan Decoction might play an important role.

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