Objective:To observe the effect of abnormal savda munziq on morphological structure of dominating organ cells in animal model of abnormal savda syndrome

to explore the essence of abnormal savda on morphology

to explore the working mechanism of abnormal savda munziq.Methods: Male ICR rats were fed with cold-natured diet under cool dry environment

and stimulated with electric shocks to establish animal model of abnormal savda syndrome in Uyghur medicine.Three other drug groups were given the same stimulative elements and further intervened with three different dosages(2.53

5.06

10.12 g·kg-1) of abnormal savda munziq during the whole procedure.In order to observe histological changes of these dominating organs by microscope

the brains

cardiac muscles and livers were prepared.Results: Microscopic examination of the model group showed swelling of hypothalamic cells

interstitial angiectasis in the hypothalamus.There was adipose cells infiltration and interstitial angiectasis on cardiac muscles. There were necrosis and inflammatory cells infiltration in liver tissues.However

the morphological changes of dominating organ cells in drug intervene groups improved significantly according to the concentration of drugs.Conclusion: Abnormal savda munziq can ptotect and recover the pathological damage on dominating organ cells in animal model of abnormal savda syndrome.