Objective:To investigate the effect of Danggui Buxue Decoction on function reconstruction of hematopoietic tissue in mice after bone marrow isotransplanttation(iso-BMT).Methods:The typical mouse model of iso-BMT was established.The model mice were randomly divided into BMT+Danggui Buxue Decoction treatment group(treated with Danggui Buxue Decoction by gastrogavage) and BMT model group(treated with normal saline by gastrogavage).PB and BM of normal mice were obtained as blank.The following parameters were observed in the day 1

11 and 22:peripheral blood cells

bone marrow mono-nuclear cells(BMMNC)

and the observation of bone marrow under microscope.Results:The levels of peripheral WBC

RBC

platelet

BMMNC

and the observation of bone marrow by microscope at the day 11 and 22 in BMT+Danggui Buxue Decoction treatment group were all significantly better than that of BMT model group(P<0.05 or P<0.01).Conclusion:Danggui Buxue Decoction could improve the function reconstruction of hematopoietic tissue.