Objective:To identify pharmacokinetics of syringopicroside in rabbits.Methods:The plasma samples were collected after intravenous injection and syringopicroside was determined by HPLC after solid-phase extraction.The data were analyzed with software Multi97 and the pharmacokinetic parameters were calculated.Results:Two compartment model was shown after syringopicroside administration.The main pharmacokinetic parameters are presented respectively: T1/2(α)=2.655 min

T1/2(β)=16.54 min

AUC=272.32 μg·mL-1·min

CL=(0.037 1 mL·min-1)

K12=(0.090 8 min-1)

K21=0.124 min-1.Conclusion:The pharmacokinetics of syringopicroside showed a rapid distribution

the elimination was also fast

and the retention time was short.