Objective: To study the influence of Sini decoction at different doses and with different preparing methods on the contracting function of the isolated toad heart.Methods: The improved toad heart-intubation method were adopted

the isolated toad hearts were perfused Sini water decoction(SWD) or Sini water-decocted and alcohol-sinked liquid(SWDASL) at different doses

the contraction tension and the contraction extent of isolated toad heart were recorded.Results: The raw Fuzi SWD and SWDASL at the low doses had the excitation effect on isolated toad heart

while at high doses had the restraint effect on isolated toad heart;the fried Fuzi SWD and SWDASL at different doses had the restraint effect on isolated toad heart.The restraint effect on isolated toad heart was weakened

after Sini decoction was treated as alcohol-sinked liquid.Conclusion: The influence of Sini decoction on the isolated toad heart were different according to the alcohol-sinked treatment and the Fuzi with different processing.