Objective:To develop an HPLC method to determin active components in Fufang Yemazhui Capsule.Methods: The mobile phase for chlorogenic acid determination consisted of acetonitrile and 0.1 mol·L-1 sodium dihydrogen phosphate buffer(pH 3.4 adjusted by Phosphoric acid)(5∶95).The mobile phase for baicalin determination consisted of methanol and 0.4%phosphoric acid(49∶51).The resolution is good enough.Results: A good linear relationship of chlorogenic acid was showed between(0.092～1.38) μg and the repeatability was fine(RSD=1.14%).The average recovery was 99.06%

(RSD=1.93%).The linear relationship of baicalin was also good between(0.084～2.52) μg.The repeatability was fine(RSD=0.63%).The average recovery was 99.22%

(RSD=0.97%).Conclusion: This method was accurate and simple.The Quality of Fufang Yemazhui Capsule cloud be controlled effectively.