CAI Xi, HUANG Hui, WANG Lan. Progress of Research on Female Animal Models of Perimenopause[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 71-73.
CAI Xi, HUANG Hui, WANG Lan. Progress of Research on Female Animal Models of Perimenopause[J]. Chinese journal of experimental traditional medical formulae, 2007, 13(10): 71-73.DOI:
Objective:To offer the references for selecting and preparing animal models of perimenopause.Methods:We summarized the studies on animal models of perimenopause in the last 10 years with analyzing and comparing the characteristics of these models.Results:In the main animal models
Ovariectomy rats or mice are freguently used.Old rat model is more similar with human being of perimenopause. According to the symptom
the multiplex models of ovariectomy rats or mice are used mostly.Conclusions:Female rat of perimenopause has been used in the study of perimenopause successfully.However
endocrine levels should be standardized for the animal models.