ZHAN Xiao-dong1, WANG Ke-xia2, LI Chao-pin1. Studies on Anti-HBV Effect in vitro of Snail Polysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 66-68.
ZHAN Xiao-dong1, WANG Ke-xia2, LI Chao-pin1. Studies on Anti-HBV Effect in vitro of Snail Polysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2008, 14(3): 66-68.DOI:
Objective:To evaluate the anti-HBV effect of snail polysaccharide(SP).Methods:HepG2.2.15 cell strain was used in vitro
and we applied Lamivudine as positive control.ELISA was adopted to detect the level of HBsAg and HBeAg in supernatant.The quantity of HBV DNA was checked by RT-PCR.The inhibition ratio was calculated of SP on HBV.Results:SP had a inhibiting effect on the HBsAg and HBeAg with maximum inhibition ratio adding up to 42.8% and 52.1% respectively.There was certain inhibition on replication of HBV DNA(P<0.05).Conclusions:SP has a noticeable anti-HBV effect in vitro with low toxicity