Objective:To study changes of several related subjects of neuro-endocrino-immune network(NEI) in asthma models

to study the effects of Epimedium Herb on NEI.Methods:54 BN rats were randomly divided into 5 groups

Group A

B

C

D and E.Group A was the normal group.Group B was the allergic asthma model.Group C

D and E were administered respectively with low

moderate and high dose Epimedium Herb.CRHmRNA

ACTH

CORT

IL-6

IL-4

IFN-γ were measured in all groups.Results:The expression of CRHmRNA in hypothalamic tissue and concentration of interferon gamma in blood both increased in controlled groups in comparison with group B.There were higher expression of CRHmRNA in group C or D than that in group B.There were higher concentration of IFN-γ in group D than that in group B.Conclusion:The rats troubled with repeated asthmatic attack for three weeks had disorders of NEI(mainly including HPA axis and several cytokines).Epimedium Herb could improve HPA axis and Th1/Th2 cytokines so as to alleviate the inflammation of asthma.