Objective:To study the effects of the Qing Xin KaiqiaoFang(QXKQF) on contents of free radicals metabolism in brain and shape hippocampal nerve cells in Alzheimer disease(AD) mice.Methods:One handred fifty mice were divid into five groups:blank group

model group

two groups of treatment by QXKQF(14.82 g·kg-1)

7.41 g·kg-1)

Piracetan comparison group(0.42 g·kg-1).The model group was orally given AlCl3(200 mg·kg-1)every day.For QXKQF and Piracetan groups

AlCl3 treatment was given 6 days at the begining

followed by giving orally AlCl3 in the morning and drug in the afternoon for 8 weeks.Then

learning and memory ability

free radicals metabolism in brain(SOD、MDA、LF) and morphology of hippocampal nerve cells were investigated.Results:QXKQF can prevent hippocampal nerve cells from damage obviously.The SOD increased

the contents of MAD and LF were lowered compared with model group(P<0.01).Learning and memory ability of QXKQF groups is improved

compared with model group(P<0.05～0.01).Conclusion:QXKQF can improve learning and memory ability of AD mice

protect hippocampal nerve cells

resist oxidation and reduce free radicals injure for AD mice.